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Proteasome substrate IV (fluorogenic)

 
ALX-260-087-M001 1 mg 57.00 USD
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Fluorogenic substrate for Alzheimer's Disease amyloid A4-generating enzymes and for the proteasome.

Product Specification

Alternative Name:Z-VKM-AMC, Z-Val-Lys-Met-AMC
 
Sequence:Z-Val-Lys-Met-AMC (AMC=7-Amino-4-methylcoumarin)
 
Formula:C34H45N5O7S
 
MW:667.8
 
Purity:≥98%
 
Appearance:Colorless amorphous solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
 

Product Literature References

Characterization of peptidyl boronic acid inhibitors of mammalian 20 S and 26 S proteasomes and their inhibition of proteasomes in cultured cells: R.C. Gardner, et al.; Biochem. J. 346, 447 (2000), Abstract; Full Text
Distribution of Alzheimer's disease amyloid A4-generating enzymes in rat brain tissue: S. Ishiura, et al.; Neurosci. Lett. 115, 329 (1990), Abstract;

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Amyloid beta
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