Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Pepstatin A (synthetic)

Protease inhibitor
 
ALX-260-085-M005 5 mg 44.00 USD
 
ALX-260-085-M025 25 mg 120.00 USD
 
ALX-260-085-M100 100 mg 360.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-PI120

Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission. Suppresses p-53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.

Product Specification

Alternative Name:Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
 
Sequence:i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
(AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
 
Formula:C34H63N5O9
 
MW:685.9
 
Source:Synthetic.
 
CAS:26305-03-3
 
MI:14: 7147
 
RTECS:SC6155000
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (10mg/ml), methanol (1mg/ml) or acetic acid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 2 years after receipt when stored at -20°C.
 
Handling:Protect from light.
 

Product Literature References

Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS: P. Ziltener, et al.; PloS One. 12, e01005591 (2016), Application(s): Cell culture, Abstract; Full Text
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia: A.S. Watson, et al.; Cell Death Discov 1, 15008 (2015), Application(s): Autophagy assay in human and mouse HSCs, Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Lysosomal Degradation of CD44 Mediates Ceramide Nanoliposome-induced Anoikis and Diminished Extravasation in Metastatic Carcinoma Cells: J. K. Haakenson, et al.; J. Biol. Chem. 290, 8632 (2015), Application(s): Cell Culture , Abstract; Full Text
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract; Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis. 4, e761 (2013), Application(s): Inhibitor of 20S proteasome for kinetics assay, Abstract; Full Text
Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62: D.H. Ball, et al.; J. Parasitol. Res. 2013, 961268 (2013), Abstract; Full Text
Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission: I. Athanassakis, et al.; Cell. Immunol. 199, 81 (2000), Abstract;
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity: G.S. Wu, et al.; Oncogene 16, 2177 (1998), Abstract;
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha: L.P. Deiss, et al. ; EMBO J. 15, 3861 (1996), Abstract;
Pepstatin, a new pepsin inhibitor produced by Actinomycetes: H. Umezawa, et al.; J. Antibiot. 23, 259 (1970), Abstract;

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,