Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Ac-LEHD-AMC

Caspase-9 substrate
 
ALX-260-080-M001 1 mg 51.00 USD
 
ALX-260-080-M005 5 mg 144.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P444

Fluorogenic substrate for caspase-9 and related cysteine proteases. The LEHD sequence is derived from combinatorial experiments. Ex.:340-360nm, Em.:440-460nm.

Product Specification

Alternative Name:Caspase-9 substrate (fluorogenic)
 
Sequence:Ac-Leu-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
 
Formula:C33H41N7O11
 
MW:711.7
 
CAS:292633-16-0
 
Peptide Content:75-95%
 
Purity:≥98%
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water,  DMSO or phosphate buffer, pH 7.5.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Keep cool and dry.
 
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
 

Product Literature References

Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin: T.L. Campbell, et al.; Data Brief 7, 786 (2016), Application(s): Assessed caspase-3, -8, and -9 activity in mixed gastrocnemius homogenates, Abstract;
Protolichesterinic acid enhances doxorubicin-induced apoptosis in HeLa cells in vitro: F. Brisdelli, et al.; Life Sci. 158, 89 (2016), Application(s): Caspase activity, Abstract;
Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway: Y. Lu, et al.; Int. J. Mol. Sci. 17, E775 (2016), Application(s): Caspase activation by Ru complexes, Abstract; Full Text
Study of commonly used organophosphate pesticides that induced oxidative stress and apoptosis in peripheral blood lymphocytes of rats: A. Ojha, et al.; Hum. Exp. Toxicol. (2016), Abstract;
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing: C. Lawlor, et al.; PLoS One 11, e0149167 (2016), Application(s): Caspase activity assays, Abstract; Full Text
Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract; Full Text
Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells: J. Hofmanova; Eur. J. Nutrition 44, 40 (2005), Abstract;
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

Product Toolbox

PRODUCT RESOURCES

Print as PDF
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Caspase
Caspase-9
By biological activity:
Caspase Substrate
Caspase-9 Substrate
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,