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Ac-LEHD-CHO

Caspase-9 inhibitor
 
ALX-260-079-M001 1 mg 80.00 USD
 
ALX-260-079-M005 5 mg 311.00 USD
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Replaces Prod. #: BML-P446

Reversible aldehyde inhibitor of caspase-9 and related cysteine proteases. Sequence is from combinatorial experiments.

Product Specification

Alternative Name:Caspase-9 inhibitor (aldehyde)
 
Sequence:Ac-Leu-Glu-His-Asp-CHO
 
Formula:C23H34N6O9
 
MW:538.6
 
Peptide Content:75-95%
 
Purity:≥95%
 
Appearance:Lyophilized.
 
Solubility:Soluble in water or DMSO. Further dilute with buffer, pH 7.5.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Keep sealed after removing from the freezer until its temperature equilibrates with room temperature. Dissolve only amount needed at a time to avoid decomposition in solution.
 
Handling:Keep cool and dry.
 

Product Literature References

Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract; Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

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