Ac-DMQD-AMC

Caspase-3 substrate



ALX-260-078-M001	1 mg	45.00 USD

ALX-260-078-M005	5 mg	155.00 USD

Fluorogenic substrate for caspase-3.

Product Specification

Alternative Name:	Caspase-3 substrate (fluorogenic)

Formula:	C₃₀H₃₈N₆O₁₂S

MW:	706.7

Purity:	≥98% (HPLC)

Appearance:	White powder.

Sequence:	Ac-Asp-Met-Gln-Asp-AMC (AMC=7-Amino-4-methylcoumarin)

Peptide Content:	75-95%.

Solubility:	Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5

Long Term Storage:	-20°C

Handling:	Keep cool and dry.

Background / Technical Information:	AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.

Product Literature References

Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells: J. Hofmanova; Eur. J. Nutrition 44, 40 (2005), Abstract;

Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract;

The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status: M. Kovarikova, et al.; Differentiation 72, 23 (2004), Abstract;