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Ac-DMQD-CHO

Caspase-3 inhibitor
 
ALX-260-077-M001 1 mg 80.00 USD
 
ALX-260-077-M005 5 mg 302.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P418

Reversible, aldehyde inhibitor of caspase-3 and related cysteine proteases. Exhibits high selectivity for caspase-3 over -1, -4, -6, and -7. Sequence is based on baculovirus p35 protein inhibitor site of cleavage. Together with the caspase-6 inhibitor Ac-VEID-CHO (Prod. No. ALX-260-062) this inhibitor has been used to dissect the pathway of caspase activation in Fas-stimulated Jurkat cells.

Product Specification

Alternative Name:Caspase-3 inhibitor (aldehyde)
 
Sequence:Ac-Asp-Met-Gln-Asp-CHO
 
Formula:C20H31N5O10S
 
MW:533.6
 
Formulation:Lyophilized.
 
Peptide Content:70-90%.
 
Purity:≥96% (HPLC)
 
Appearance:White powder.
 
Solubility:Soluble in DMSO or distilled water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C.
 
Handling:Keep cool and dry.
 

Product Literature References

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis: H. Hirata, et al.; J. Exp. Med. 187, 587 (1998), Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;
Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease: J. Bertin et al.; J. Virol. 70, 6251 (1996), Abstract;

Related Products

Ac-VEID-CHO 

Inhibitor of caspase-6, -8 and -10
≥95% (HPLC) | Print as PDF
 
ALX-260-062-M001 1 mg 104.00 USD
 
ALX-260-062-M005 5 mg 404.00 USD
Do you need bulk/larger quantities?
 

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