Ac-DMQD-CHO

Caspase-3 inhibitor



ALX-260-077-M001	1 mg	67.00 USD

ALX-260-077-M005	5 mg	251.00 USD

Replaces Prod. #: BML-P418

Reversible, aldehyde inhibitor of caspase-3 and related cysteine proteases. Exhibits high selectivity for caspase-3 over -1, -4, -6, and -7. Sequence is based on baculovirus p35 protein inhibitor site of cleavage. Together with the caspase-6 inhibitor Ac-VEID-CHO (Prod. No. ALX-260-062) this inhibitor has been used to dissect the pathway of caspase activation in Fas-stimulated Jurkat cells.

Product Specification

Alternative Name:	Caspase-3 inhibitor (aldehyde)

Formula:	C₂₀H₃₁N₅O₁₀S

MW:	533.6

Purity:	≥96% (HPLC)

Appearance:	White powder.

Sequence:	Ac-Asp-Met-Gln-Asp-CHO

Formulation:	Lyophilized.

Peptide Content:	70-90%.

Solubility:	Soluble in DMSO or distilled water.

Long Term Storage:	-20°C

Use/Stability:	Stock solutions should be divided into aliquots and stored at -20°C.

Handling:	Keep cool and dry.

Product Literature References

Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis: H. Hirata, et al.; J. Exp. Med. 187, 587 (1998), Abstract;

Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;

Apoptotic suppression by baculovirus P35 involves cleavage by and inhibition of a virus-induced CED-3/ICE-like protease: J. Bertin et al.; J. Virol. 70, 6251 (1996), Abstract;