Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Z-IE(OMe)TD(OMe)-FMK

Caspase and granzyme inhibitor
 
ALX-260-073-M001 1 mg 252.00 USD
 
ALX-260-073-M005 5 mg 1,326.00 USD
Do you need bulk/larger quantities?
 
Irreversible, cell permeable inhibitor of caspase-8 and granzyme B. Inhibits also caspase-10.

Product Specification

Alternative Name:Caspase-8 inhibitor (fluoromethylketone), Granzyme B inhibitor (fluoromethylketone)
 
Sequence:Z-Ile-Glu(OMe)-Thr-Asp(OMe)-fluoromethylketone
 
Formula:C30H43FN4O11
 
MW:654.7
 
Purity:≥95% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store stock solutions in aliquots at -20°C.
 
Handling:Packaged under inert gas.
 
Technical Info/Product Notes:We recommend a final concentration of 2µM for inhibiting caspase activity in Jurkat cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Reconstitution of caspase-8 sensitizes JB6 cells to TRAIL: I.K. Kim, et al.; BBRC 277, 311 (2000), Abstract;
Caspase-mediated proteolysis and activation of protein kinase Cδ plays a central role in neutrophil apoptosis: A. Khwaja & L. Tatton; Blood 94, 291 (1999), Abstract; Full Text
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide: E.A. Sweeney, et al.; FEBS Lett. 425, 61 (1998), Abstract;
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signal: D.A. Martin, et al.; J. Biol. Chem. 273, 4345 (1998), Abstract; Full Text
Role of caspases in immunotoxin-induced apoptosis of cancer cells: A. Keppler-Hafkemeyer, et al.; Biochemistry 37, 16934 (1998), Abstract;

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,