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Z-D(OMe)E(OMe)VD(OMe)-FMK

Inhibitor of caspase-3 and -7
 
ALX-260-072-M001 1 mg 286.00 USD
 
ALX-260-072-M005 5 mg 1,043.00 USD
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Irreversible, cell permeable inhibitor of caspase-3 and -7.

Product Specification

Alternative Name:Caspase-3 inhibitor (fluoromethylketone), Caspase-7 inhibitor (fluoromethylketone)
 
Sequence:Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
 
Formula:C30H41FN4O12
 
MW:668.7
 
Formulation:Lyophilized.
 
Purity:≥95% (TLC)
 
Solubility:Soluble in DMSO (20mM) or dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for 1 year after receipt when stored at -20°C.
 
Handling:Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
 
Technical Info/Product Notes:We recommend a final concentration of 2-10µM for inhibiting caspase activity in cell culture. The optimal doses may vary for different cells and culture conditions.
 

Product Literature References

Caspase-3-dependent and -independent degradation of 28 S ribosomal RNA may be involved in the inhibition of protein synthesis during apoptosis initiated by death receptor engagement: D. Nadano & T.A. Sato; J. Biol. Chem. 275, 13967 (2000), Abstract; Full Text
Connective tissue growth factor induces apoptosis via caspase 3 in cultured human aortic smooth muscle cells: K. Hishikawa, et al.; Eur. J. Pharmacol. 392, 19 (2000), Abstract;
The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule cells is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32: D. Vaudry, et al.; PNAS 97, 13390 (2000), Abstract; Full Text
Activation of caspase-3 in the retina of transgenic rats with the rhodopsin mutation s334ter during photoreceptor degeneration: C. Liu, et al.; J. Neurosci. 19, 4778 (1999), Abstract; Full Text
Caspase-8 mediates caspase-3 activation and cytochrome c release during singlet oxygen-induced apoptosis of HL-60 cells: S. Zhuang, et al.; Exp. Cell Res. 250, 203 (1999), Abstract;
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury: Y. Cheng, et al.; J. Clin. Invest. 101, 1992 (1998), Abstract;
Geranylgeraniol potently induces caspase-3-like activity during apoptosis in human leukemia U937 cells: Y. Masuda, et al.; BBRC 234, 641 (1997), Abstract;
CPP32/apopain is a key interleukin 1 β converting enzyme-like protease involved in Fas-mediated apoptosis: J. Schlegel, et al.; J. Biol. Chem. 271, 1841 (1996), Abstract; Full Text
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis: D.W. Nicholson; Nature Biotechnol. 14, 297 (1996), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;

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