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Ac-VEID-CHO

Inhibitor of caspase-6, -8 and -10
 
ALX-260-062-M001 1 mg 104.00 USD
 
ALX-260-062-M005 5 mg 404.00 USD
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Replaces Prod. #: BML-P440

Reversible aldehyde inhibitor of caspase-6. Also inhibits caspase-8 and -10. Sequence is based on lamin A site of cleavage.

Product Specification

Alternative Name:Caspase-6 inhibitor (aldehyde)
 
Sequence:Ac-Val-Glu-Ile-Asp-CHO
 
Formula:C22H36N4O9
 
MW:500.6
 
Formulation:Lyophilized.
 
Peptide Content:70-90%.
 
Purity:≥95% (HPLC)
 
Appearance:White powder.
 
Solubility:Soluble in DMSO or water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C. The solution is stable for weeks when stored at -20°C and protected from light. Do not dissolve in aqueous buffer due to possible racemization.
 
Handling:Keep cool and dry.
 

Product Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula et al.; J. Biol. Chem. 271, 27099 (1996), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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