Replaces Prod. #: BML-P440
Reversible aldehyde inhibitor of caspase-6. Also inhibits caspase-8 and -10. Sequence is based on lamin A site of cleavage.
Product Details
| Alternative Name: | Caspase-6 inhibitor (aldehyde) |
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| Sequence: | Ac-Val-Glu-Ile-Asp-CHO |
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| Formula: | C22H36N4O9 |
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| MW: | 500.6 |
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| Formulation: | Lyophilized. |
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| Peptide Content: | 70-90%. |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White powder. |
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| Solubility: | Soluble in DMSO or water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. The solution is stable for weeks when stored at -20°C and protected from light. Do not dissolve in aqueous buffer due to possible racemization. |
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| Handling: | Keep cool and dry. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-7: E.S. Okerberg, et al.; Biochemistry
58, 5320 (2019),
Abstract;
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding: K.B. Dagbay, et al.; J. Biol. Chem.
292, 4885 (2017),
Abstract;
Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem.
272, 17907 (1997),
Abstract;
Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem.
272, 9677 (1997),
Abstract;
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula et al.; J. Biol. Chem.
271, 27099 (1996),
Abstract;
