Ac-VEID-CHO

Inhibitor of caspase-6, -8 and -10



ALX-260-062-M001	1 mg	90.00 USD

ALX-260-062-M005	5 mg	352.00 USD

Replaces Prod. #: BML-P440

Reversible aldehyde inhibitor of caspase-6. Also inhibits caspase-8 and -10. Sequence is based on lamin A site of cleavage.

Product Specification

Alternative Name:	Caspase-6 inhibitor (aldehyde)

Formula:	C₂₂H₃₆N₄O₉

MW:	500.6

Purity:	≥95% (HPLC)

Appearance:	White powder.

Sequence:	Ac-Val-Glu-Ile-Asp-CHO

Formulation:	Lyophilized.

Peptide Content:	70-90%.

Solubility:	Soluble in DMSO or water.

Long Term Storage:	-20°C

Use/Stability:	Stock solutions should be divided into aliquots and stored at -20°C. The solution is stable for weeks when stored at -20°C and protected from light. Do not dissolve in aqueous buffer due to possible racemization.

Handling:	Keep cool and dry.

Product Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

Substrate specificities of caspase family proteases: R.V. Talanian et al.; J. Biol. Chem. 272, 9677 (1997), Abstract;

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32: S.M. Srinivasula et al.; J. Biol. Chem. 271, 27099 (1996), Abstract;