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Ac-WEHD-AMC

Substrate for caspase-1, -4 and -5
 
ALX-260-057-M001 1 mg 92.00 USD
 
ALX-260-057-M005 5 mg 160.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P452

Fluorogenic substrate for caspase-1 (Km=4µM), -4 (Km=31µM);and -5 (Km=15µM). This fluorogenic caspase-1 substrate with an optimal tetrapeptide sequence is cleaved 50-fold more efficiently than Ac-YVAD-AMC (Prod. No. ALX-260-024).

Product Specification

Alternative Name:Caspase-1 substrate (fluorogenic), Caspase-5 substrate (fluorogenic), Caspase-4 substrate (fluorogenic)
 
Sequence:Ac-Trp-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
 
Formula:C38H40N8O11
 
MW:784.8
 
Formulation:Lyophilized.
 
Peptide Content:70-90%
 
Purity:≥98% (HPLC)
 
Solubility:Soluble in DMSO (100mM, 75.5mg/ml). Dilute with distilled water or buffer.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
 

Product Literature References

Synthesis of a small molecule nitrosocysteine inhibitor to reduce the activity of Caspase-1: C.A. Shamblen & C.E. Karver; DePaul Discoveries 5, Article 5 (2016), Application(s): Caspase-1 inhibition assay, Full Text
CD 95-independent mechanisms of IL-2 deprivation-induced apoptosis in activated human lymphocytes: T. Hieronymus, et al.; Cell Death Differ. 7, 538 (2000), Abstract;
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo, et al.; Cell Death Differ. 6, 362 (1999), Application(s): Kinetic constants for cleavage of fluorescent substrates, Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract; Full Text

Related Products

Ac-YVAD-AMC 

Caspase-1 substrate
≥98% (HPLC) | Print as PDF
 
ALX-260-024-M001 1 mg 43.00 USD
 
ALX-260-024-M005 5 mg 123.00 USD
Do you need bulk/larger quantities?
 

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