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Ac-ESMD-CHO

Caspase and granzyme inhibitor
 
ALX-260-056-M001 1 mg 66.00 USD
 
ALX-260-056-M005 5 mg 322.00 USD
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Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.

Product Specification

Alternative Name:Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)
 
Sequence:Ac-Glu-Ser-Met-Asp-CHO
 
Formula:C19H30N4O10S
 
MW:506.5
 
Formulation:Lyophilized.
 
Peptide Content:70-90%.
 
Purity:≥99% (HPLC)
 
Appearance:White powder.
 
Solubility:Soluble in distilled water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Use always fresh solutions.
 
Handling:Keep under inert gas. Keep cool and dry.
 

Product Literature References

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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