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Ac-AAVALLPAVLLALLAPDEVD-CHO

Caspase inhibitor
 
ALX-260-046-M001 1 mg 87.00 USD
 
ALX-260-046-M005 5 mg 360.00 USD
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Replaces Prod. #: BML-P414

Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.

Product Specification

Alternative Name:Caspase-3 inhibitor (aldehyde)
 
Sequence:Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
 
Formula:C94H158N20O27
 
MW:2000.4
 
Formulation:Lyophilized. TFA salt.
 
Peptide Content:65-95%.
 
Purity:≥95% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:After dissolving, prepare aliquots and store at -20°C. Keep cool and dry.
 

Product Literature References

Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med. 186, 1107 (1997), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell 81, 801 (1995), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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