Ac-IETD-CHO

Caspase and granzyme inhibitor



ALX-260-043-M001	1 mg	64.00 USD

ALX-260-043-M005	5 mg	251.00 USD

Replaces Prod. #: BML-P430

Reversible inhibitor of caspase-6, -8 and granzyme B. Also inhibits caspase-10.

Product Specification

Alternative Name:	Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)

Formula:	C₂₁H₃₄N₄O₁₀

MW:	502.5

Purity:	≥97% (HPLC)

Sequence:	Ac-Ile-Glu-Thr-Asp-CHO

Formulation:	Lyophilized.

Peptide Content:	70-90%.

Solubility:	Soluble in distilled water.

Long Term Storage:	-20°C

Use/Stability:	Use always fresh solutions.

Product Literature References

Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract;

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract; Full Text