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Ac-IETD-CHO

Caspase and granzyme inhibitor
 
ALX-260-043-M001 1 mg 77.00 USD
 
ALX-260-043-M005 5 mg 302.00 USD
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Replaces Prod. #: BML-P430

Reversible inhibitor of caspase-6, -8 and granzyme B. Also inhibits caspase-10.

Product Specification

Alternative Name:Caspase-8 inhibitor (aldehyde), Granzyme B inhibitor (aldehyde)
 
Sequence:Ac-Ile-Glu-Thr-Asp-CHO
 
Formula:C21H34N4O10
 
MW:502.5
 
CAS:191338-86-0
 
Formulation:Lyophilized.
 
Peptide Content:70-90%
 
Purity:≥96% (HPLC)
 
Solubility:Soluble in distilled water at 10 mg/mL and in DMSO at 1 mg/mL.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Use always fresh solutions.
 

Product Literature References

Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract;
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract;
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract; Full Text

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For Research Use Only. Not for use in diagnostic procedures.
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