Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Ac-IETD-AMC

Caspase and granzyme substrate
 
ALX-260-042-M001 1 mg 47.00 USD
 
ALX-260-042-M005 5 mg 149.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-P432

Fluorogenic substrate for caspase-6 and -8 and granzyme B. Also a substrate for caspase-10.

Product Specification

Alternative Name:Granzyme B substrate (fluorogenic), Caspase-8 substrate (fluorogenic)
 
Sequence:Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
 
Formula:C31H41N5O12
 
MW:675.7
 
Peptide Content:70-90%
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO. Dilute with buffer, pH 7.5.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light. Keep cool and dry.
 
Technical Info/Product Notes:AMC has an excitation maximum of 340-360nm and an emission maximum of 440-460nm.
 

Product Literature References

Ruthenium Complexes Induce HepG2 Human Hepatocellular Carcinoma Cell Apoptosis and Inhibit Cell Migration and Invasion through Regulation of the Nrf2 Pathway: Y. Lu, et al.; Int. J. Mol. Sci. 17, E775 (2016), Application(s): Caspase activation by Ru complexes, Abstract; Full Text
Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing: C. Lawlor, et al.; PLoS One 11, e0149167 (2016), Application(s): Caspase activity assays, Abstract; Full Text
Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004), Abstract;
Activation of a CrmA-insensitive, p35-sensitive pathway in ionizing radiation-induced apoptosis: R. Datta, et al.; J. Biol. Chem. 272, 1965 (1997), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract;
Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract;

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,