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Z-Asp-2,6-dichlorobenzoyloxymethylketone

Caspase inhibitor



ALX-260-029-M050	50 mg	594.00 USD
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Replaces Prod. #: BML-P415

Irreversible, cell permeable broad-spectrum caspase inhibitor.
Caspase-3 IC₅₀: 1,1µM
Caspase-6 IC₅₀: 4,1µM
Less effective on the inhibition of caspase-1- and 8-like activities.
Inhibits hypoxia-induced apoptosis in neuroblastoma cells.

Product Details

Alternative Name:	Caspase family inhibitor, Z-Asp-CH2-DCB, Z-L-Asp-a-[2,6-(dichlorobenzoyl)oxy]methane

Formula:	C₂₀H₁₇Cl₂NO₇

MW:	454.3

CAS:	153088-73-4

Purity:	≥98% (TLC)

Appearance:	White to off-white powder.

Solubility:	Soluble in methanol (50mg/ml) or DMSO.

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Stock solutions should be divided into aliquots and stored at -20°C.

Handling:	Keep cool and dry.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation: T. Krakauer; Clin. Diagn. Lab. Immunol. 11, 621 (2004), Abstract; Full Text

Long-term caspase inhibition ameliorates apoptosis, reduces myocardial troponin-I cleavage, protects left ventricular function, and attenuates remodeling in rats with myocardial infarction: Y. Chandrashekhar, et al.; J. Am. Coll. Cardiol. 43, 295 (2004), Abstract;

Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension: L. Taraseviciene-Stewart; FASEB J. 15, 427 (2001), Abstract; Full Text

Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2',3',4'-trimethoxyphenyl)-2,4,6-cycloheptatrien-1 -one: protection by Bcl-2 and Bcl-X(L) and cell cycle arrest: C. Gajate, et al.; Cancer Res. 60, 2651 (2000), Abstract; Full Text

Involvement of mitochondria and caspase-3 in ET-18-OCH(3)-induced apoptosis of human leukemic cells: C. Gajate, et al.; Int. J. Cancer 86, 208 (2000), Abstract;

LPS-induced signals in activation of caspase-3-like protease, a key enzyme regulating apoptotic cell damage into a macrophage-like cell line, J774.1, in the presence of cycloheximide: H. Karahashi & F. Amano; J. Leukoc. Biol. 66, 689 (1999), Abstract; Full Text

Tumor necrosis factor-alpha and lipopolysaccharide induce apoptotic cell death in bovine glomerular endothelial cells: U.K. Messmer et al.; Kidney Int. 55, 2322 (1999), Abstract; Full Text

Hypoxia induces apoptosis in human neuroblastoma SK-N-MC cells by caspase activation accompanying cytochrome c release from mitochondria: R. Araya, et al.; FEBS Lett. 439, 168 (1998), Abstract;

Aspartate-based inhibitor of interleukin-1 beta-converting enzyme prevents antitumor agent-induced apoptosis in human myeloid leukemia U937 cells: T. Mashima, et al.; BBRC 209, 907 (1995), Abstract;

P1 aspartate-based peptide alpha-((2,6-dichlorobenzoyl)oxy)methyl ketones as potent time-dependent inhibitors of interleukin-1 beta- converting enzyme: R.E. Dolle, et al.; J. Med. Chem. 37, 563 (1994), Abstract;