Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.
Product Details
| Alternative Name: | Caspase-1 inhibitor (chloromethylketone) |
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| Sequence: | Ac-Tyr-Val-Ala-Asp-chloromethylketone |
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| Formula: | C24H33N4O8Cl |
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| MW: | 541.0 |
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| CAS: | 178603-78-6 |
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| Purity: | ≥96% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in DMSO (50mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions should be divided into aliquots and stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on KATP channel activation: B. Schnabel, et al.; Mol. Vis.
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Abstract;
A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation: J.W. Lee, et al.; Biochem. Biophys. Res. Commun. (2016),
Application(s): Cell culture,
Abstract;
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis: M.V. Nastase, et al.; Am. J. Pathol.
186, 1206 (2016),
Abstract;
Enzymatically Inactive Procaspase-1 stabilizes the ASC-Pyroptosome and supports Pyroptosome Spreading during Cell Division: R. Stein, et al.; J. Biol. Chem.
291, 18419 (2016),
Application(s): Measuring enzymatic activity of caspase-1,
Abstract;
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5: M. Matusiak, et al.; PNAS
112, 1541 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses: G. Mathiak, et al.; Br. J. Pharmacol.
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Abstract;
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis: N. Rouquet, et al.; Curr. Biol.
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Abstract;
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Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell
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Abstract;
