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Ac-YVAD-CMK

Inhibitor of caspase-1 and -4
 
ALX-260-028-M001 1 mg 87.00 USD
 
ALX-260-028-M005 5 mg 320.00 USD
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Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.

Product Specification

Alternative Name:Caspase-1 inhibitor (chloromethylketone)
 
Sequence:Ac-Tyr-Val-Ala-Asp-chloromethylketone
 
Formula:C24H33N4O8Cl
 
MW:541.0
 
CAS:178603-78-6
 
Purity:≥96% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in DMSO (50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C.
 

Product Literature References

A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation: J.W. Lee, et al.; Biochem. Biophys. Res. Commun. (2016), Application(s): Cell culture, Abstract;
Enzymatically Inactive Procaspase-1 stabilizes the ASC-Pyroptosome and supports Pyroptosome Spreading during Cell Division: R. Stein, et al.; J. Biol. Chem. 291, 18419 (2016), Application(s): Measuring enzymatic activity of caspase-1, Abstract;
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5: M. Matusiak, et al.; PNAS 112, 1541 (2015), Application(s): Cell Culture, Abstract; Full Text
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses: G. Mathiak, et al.; Br. J. Pharmacol. 131, 383 (2000), Abstract;
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis: N. Rouquet, et al.; Curr. Biol. 6, 1192 (1996), Abstract;
Involvement of interleukin-1 beta-converting enzyme in apoptosis of bFGF-deprived murine aortic endothelial cells: S. Kondo, et al.; FASEB J. 10, 1192 (1996), Abstract;
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract;
Involvement of an ICE-like protease in Fas-mediated apoptosis: M. Enari, et al.; Nature 375, 78 (1995), Abstract;
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994), Abstract;
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994), Abstract;

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