Replaces Prod. #: BML-EI212
Inhibits aminopeptidases like aminopeptidase B, leucine aminopeptidase, tripeptide aminopeptidase, aminopeptidases on the surface of mammalian cells. Does not inhibit carboxypeptidases. May be used in in vitro translation system to inhibit the aminopeptidases found in reticulocate or wheat germ lysates. Activates macrophages and T lymphocytes. Immunomodulator. Has antitumor properties and enhances not only blastogenesis and lymphocytes in vitro, but also establishes a delayed-type hypersensitivity in vivo.
Product Details
| Alternative Name: | [(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-L-leucine . HCl |
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| Formula: | C16H24N2O4. HCl |
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| MW: | 308.4 . 36.5 |
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| Source: | Synthetic. |
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| CAS: | 65391-42-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | Soluble in methanol, acetic acid, DMSO, dimethyl formamide or 100% ethanol; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions in organic solvents are stable for 1 month at -20°C. We do not recommend storing aqueous solutions for more than one day. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
3-Amino-2-hydroxy-propionaldehyde and 3-amino-1-hydroxy-propan-2-one derivatives: new classes of aminopeptidase inhibitors: C. Tarnus, et al.; Bioorg. Med. Chem.
4, 1287 (1996),
Abstract;
Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes: L. Orning, et al.; J. Biol. Chem.
266, 1375 (1991),
Abstract;
The slow, tight binding of bestatin and amastatin to aminopeptidases: S.H. Wilkes & J.M. Prescott; J. Biol. Chem.
260, 13154 (1985),
Abstract;
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem.
27, 417 (1984),
Abstract;
Low-molecular-weight enzyme inhibitors of microbial origin: H. Umezawa; Ann. Rev. Microbiol.
36, 75 (1982),
Abstract;
Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes: H. Umezawa, et al.; J. Antibiot.
29, 97 (1976),
Abstract;
