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Leupeptin (synthetic)

Cathepsin B inhibitor
 
ALX-260-009-M005 5 mg 41.00 USD
 
ALX-260-009-M025 25 mg 131.00 USD
 
ALX-260-009-M100 100 mg 460.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: BML-PI118

Competitive and reversible inhibitor of serine and cysteine proteinases like calpain, porcine kallikrein, trypsin, plasmin, papain and cathepsin B. Does not inhibit chymotrypsin and thrombin. Also known to inhibit activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors.

Product Specification

Alternative Name:Acetyl-L-leucyl-L-leucyl-L-argininal . hemisulfate
 
Formula:C20H38N6O4 . 0.5 H2SO4
 
MW:426.6 . 49.0
 
Source:Synthetic.
 
CAS:103476-89-7
 
MI:14: 5456
 
Purity:≥97% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in water, methanol or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light and moisture.
 
Technical Info/Product Notes:Leupeptin gives multiple peaks on HPLC due to equilibria among three forms in solution. Purity determined using three main peaks. Majority of contaminating peptide is racemized leupeptin.
 

Product Literature References

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract; Full Text
Ceramide-induced apoptosis occurs independently of caspases and is decreased by leupeptin: M.A. Belaud-Rotureau, et al.; Cell Death Differ. 6, 788 (1999), Abstract;
A protease-dependent TCR-induced death pathway in mature lymphocytes: A. Sarin, et al.; J. Immunol. 154, 5806 (1995), Abstract;
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors: A. Sarin, et al.; J. Immunol. 153, 862 (1994), Abstract;
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts: J.P. Montenez, et al.; Toxicol. Lett. 73, 201 (1994), Abstract;
Isolation and characterization of leupeptins produced by Actinomycetes: S. Kondo, et al.; Chem. Pharm. Bull. 17, 1896 (1969), Abstract;

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