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E-64

Protease inhibitor
 
ALX-260-007-M005 5 mg 85.00 USD
 
ALX-260-007-M025 25 mg 304.00 USD
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Replaces Prod. #: BML-PI105

Irreversible inhibitor of cysteine proteinases like papain, calpain, cathepsin B, L and H. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases. Inhibits degradation of autophagic cargo in autophagolysosomes.

Product Specification

Alternative Name:N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine, L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane
 
Formula:C15H27N5O5 . 0.5 H20
 
MW:357.4
 
Source:Synthetic.
 
CAS:66701-25-5
 
Purity:≥98%
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water/ethanol 1:1 mixture (15 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
ALX-260-007
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ALX-260-007

Product Literature References

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract; Full Text
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai, et al.; Chem. Pharm. Bull. (Tokyo) 35, 1098 (1987), Abstract;
K. Hanada, et al.; Agric. Biol. Chem. 42, 523 (1978),
K. Hanada, et al.; Agric. Biol. Chem. 42, 529 (1978),

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