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Amastatin . hydrochloride

Aminopeptidase inhibitor
 
ALX-260-003-M001 1 mg 57.00 USD
 
ALX-260-003-M005 5 mg 185.00 USD
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Competitive inhibitor of human serum aminopeptidase A, pig kidney leucine aminopeptidase, leucine aminopeptidase, tyrosine aminopeptidase, but not of aminopeptidase B. Has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases.

Product Specification

Alternative Name:[(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
 
Formula:C21H38N4O8 . HCl
 
MW:474.6 . 36.5
 
Source:Synthetic.
 
CAS:100938-10-1
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white powder.
 
Solubility:Soluble in acetic acid.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
ALX-260-003 structure
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ALX-260-003 structure

Product Literature References

Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem. 27, 417 (1984), Abstract;
H. Tobe, et al.; Agric. Biol. Chem. 43, 591 (1979),
Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes: T. Aoyagi, et al.; J. Antibiot. (Tokyo) 31, 636 (1978), Abstract;

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