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Dimethylargininase-1 polyclonal antibody

 
ALX-215-066-R100 100 µl 280.00 USD
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Product Specification

Alternative Name:Dimethylarginine dimethylaminohydrolase 1, DDAH-1
 
Host:Rabbit
 
Immunogen:Full length bovine dimethylargininase 1 (DDAH-1).
 
UniProt ID:P56965
 
Species reactivity:Human, Mouse
Bovine, Porcine
 
Crossreactivity:Does not cross-react with DDAH-2.
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:5,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~35kDa by Western blot.
 
Formulation:Liquid. Neat serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Scientific Background:Dimethylargininase (DDAH) is a Cys-hydrolase, which, through catabolism of mono- and dimethylated derivatives of L-arginine, regulates the activity of nitric oxide synthase. DDAH-1 is mainly present in tissues expressing the constitutive forms of nitric oxide synthase such as brain and kidney.
 

Product Literature References

Toward the Development of Inhibitors Directed against Mammalian DDAH Proteins: Considerations from Homology Modeling of DDAH-2 and DDAH Activity Tracing in Tissue Homogenate: M. Knipp; Lett. Drug Des. Discov. 4, 570 (2007), Abstract;
Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease: M.A. Smith, et al.; Free Radic. Biol. Med. 25, 898 (1998), Abstract;

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