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HERG2 polyclonal antibody

 
ALX-215-052-R100 100 µl 190.00 USD
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Product Specification

Alternative Name:Ether-a-go-go related protein 2, KCNH6, Voltage-gated potassium channel subfamily H member 6, Voltage-gated potassium channel Kv11.2, Erg2
 
Host:Rabbit
 
Immunogen:Recombinant human HERG2 (ether-a-go-go related protein 2) (aa 907-986).
 
UniProt ID:Q9H252
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes HERG2 and mouse Erg2.
 
Applications:ICC, IHC (FS), IHC (PS)
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections and paraffin sections, 1:100-1:400)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In 100mM TRIS containing 100mM glycine.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-80°C
 
Scientific Background:The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
 

Product Literature References

Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;

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