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HERG1B polyclonal antibody

ALX-215-051-R100 100 µl 341.00 USD
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Product Specification

Alternative Name:Ether-a-go-go related protein 1B, KCNH2 (isoform B), Voltage-gated potassium channel subfamily H member 2 (isoform B), Voltage-gated potassium channel Kv11.1 (isoform B), Erg1B
Immunogen:Synthetic peptide corresponding to aa 15-28 (R15PRAQKGRVRRAVR28) of HERG1B (human ether-a-go-go related protein 1B).
UniProt ID:Q12809
Species reactivity:Human, Mouse
Specificity:Recognizes HERG1B and mouse Erg1B isoform.
Applications:ICC, IHC (FS), WB
Purity Detail:Affinity purified.
Formulation:Liquid. In 100mM TRIS containing 100mM glycine.
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Shipping:Shipped on Blue Ice
Short Term Storage:-20°C
Long Term Storage:-80°C
Scientific Background:The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Product Literature References

Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008), Abstract;
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;

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