HERG1B, pAb



ALX-215-051-R100	100 µl	287.00 USD

Product Specification

Alternative Name:	Ether-a-go-go related protein 1B, KCNH2 (isoform B), Voltage-gated potassium channel subfamily H member 2 (isoform B), Voltage-gated potassium channel Kv11.1 (isoform B), Erg1B

Purity Detail:	Affinity purified.

Formulation:	Liquid. In 100mM TRIS containing 100mM glycine.

Immunogen:	Synthetic peptide corresponding to aa 15-28 (R¹⁵PRAQKGRVRRAVR²⁸) of HERG1B (human ether-a-go-go related protein 1B).

Source/Host:	From rabbit.

Specificity:	Recognizes HERG1B and mouse Erg1B isoform.

Application:	Immunocytochemistry Immunohistochemistry (frozen sections) Western Blot Optimal conditions must be determined individually for each application.

Short Term Storage:	-20°C

Long Term Storage:	-80°C

Handling:	After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles.

Miscellaneous/General:	The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Product Literature References

Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008), Abstract;

Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;

Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text

Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;