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HERG1A (NT) polyclonal antibody

 
ALX-215-050-R100 100 µl 291.00 USD
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Product Specification

Alternative Name:Ether-a-go-go related protein 1A, KCNH2 (isoform A), Voltage-gated potassium channel subfamily H member 2 (isoform A), Voltage-gated potassium channel Kv11.1 (isoform A), Erg1A
 
Host:Rabbit
 
Immunogen:Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).
 
UniProt ID:Q12809
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:50-1:200)
Immunohistochemistry (frozen sections and paraffin sections, 1:100-1:400)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Neat serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
 

Product Literature References

HERG1A potassium channel is the predominant isoform in head and neck squamous cell carcinomas: evidence for regulation by epigenetic mechanisms: S. T. Menendez, et al.; Sci. Rep. 6, 19666 (2016), Application(s): Immunohistochemistry, Abstract; Full Text
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text
Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;
Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003), Abstract; Full Text
HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000), Abstract;

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