HERG1A (NT), pAb



ALX-215-050-R100	100 µl	257.00 USD

Product Specification

Alternative Name:	Ether-a-go-go related protein 1A, KCNH2 (isoform A), Voltage-gated potassium channel subfamily H member 2 (isoform A), Voltage-gated potassium channel Kv11.1 (isoform A), Erg1A

Formulation:	Liquid. Neat serum.

Immunogen:	Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1-135).

Source/Host:	From rabbit.

Specificity:	Recognizes N-terminal epitope of HERG1A and mouse Erg1A isoform.

Application:	Immunocytochemistry (1:50-1:200) Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400) Immunoprecipitation (5µl/1.5mg protein)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Miscellaneous/General:	The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Product Literature References

Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;

Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text

Interneurons transiently express the ERG K+ channels during development of mouse spinal networks in vitro: F. Furlan, et al.; Neuroscience 135, 1179 (2005), Abstract;

Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells: O. Crociani, et al.; J. Biol. Chem. 278, 2947 (2003), Abstract; Full Text

HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium: A. Cherubini, et al.; Br. J. Cancer 83, 1722 (2000), Abstract;