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HERG1 (CT) (pan) polyclonal antibody

 
ALX-215-049-R100 100 µl 323.00 USD
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Product Specification

Alternative Name:Ether-a-go-go related protein 1 (pan), KCNH2 (pan), Voltage-gated potassium channel subfamily H member 2 (pan), Voltage-gated potassium channel Kv11.1 (pan), Erg1 (pan)
 
Host:Rabbit
 
Immunogen:Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).
 
UniProt ID:Q12809
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.
 
Applications:Flow Cytometry, IHC (FS), IHC (PS), WB
 
Recommended Dilutions/Conditions:Flow Cytometry (1:1,000)
Immunocytochemistry (1:100-1:200)
Immunohistochemistry (frozen sections and paraffin sections, 1:100-1:400)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Neat serum.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:The ether-a-go-go related gene family of K+ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.
 

Product Literature References

Dominant Negative Consequences of a hERG 1b-Specific Mutation Associated with Intrauterine Fetal Death: D.K. Jones, et al.; Prog. Biophys. Mol. Biol. 120, 67 (2016), Application(s): Western blotting and Co-immunoprecipitation, Abstract;
Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008), Abstract;
Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;
hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005), Abstract;
Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text
herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004), Abstract; Full Text

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