HERG1 (CT) (pan), pAb



ALX-215-049-R100	100 µl	287.00 USD

Product Specification

Alternative Name:	Ether-a-go-go related protein 1 (pan), KCNH2 (pan), Voltage-gated potassium channel subfamily H member 2 (pan), Voltage-gated potassium channel Kv11.1 (pan), Erg1 (pan)

Formulation:	Liquid. Neat serum.

Immunogen:	Recombinant HERG1 (human ether-a-go-go related protein 1) (aa 1106-1158).

Source/Host:	From rabbit.

Specificity:	Recognizes C-terminal epitope of HERG1 and mouse Erg1. Recognizes both isoforms HERG1A and HERG1B.

Application:	Flow Cytometry (1:1'000) Immunocytochemistry (1:100-1:200) Immunohistochemistry (frozen sections, paraffin sections) (1:100-1:400) Western Blot (1:1'000)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Miscellaneous/General:	The ether-a-go-go related gene family of K⁺ channels (HERG/Erg) comprises three members, HERG1/Erg1, HERG2/Erg2, HERG3/Erg3. HERG channel activity is relevant to tumor cell biology. It controls cell proliferation, especially in leukaemias. HERG channels are thus considered novel diagnostic and prognostic factors in human cancers, as well as targets for anti-neoplastic therapies.

Product Literature References

Identification of a post-translational mechanism for the regulation of hERG1 K+ channels expression and hERG1 current density in tumor cells: L. Guasti, et al.; Mol. Cell. Biol. 28, 5043 (2008), Abstract;

Expression pattern of the ether-a-go-go-related (ERG) family proteins in the adult mouse central nervous system: evidence for coassembly of different subunits: L. Guasti, et al.; J. Comp. Neurol. 491, 157 (2005), Abstract;

hERG1 channels are overexpressed in glioblastoma multiforme and modulate VEGF secretion in glioblastoma cell lines: A. Masi, et al.; Br. J. Cancer 93, 781 (2005), Abstract;

Human ether-a-go-go-related gene 1 channels are physically linked to beta1 integrins and modulate adhesion-dependent signaling: A. Cherubini, et al.; Mol. Biol. Cell 16, 2972 (2005), Abstract; Full Text

herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells: E. Lastraioli, et al.; Cancer Res. 64, 606 (2004), Abstract; Full Text