Purinergic receptor P2X7 (mouse), pAb



ALX-215-035-R100	100 µl	234.00 USD

Product Specification

Alternative Name:	P2X purinoceptor 7, P2RX7

Formulation:	Liquid. Antiserum diluted with PBS containing 0.1% BSA and 0.02% sodium azide.

Immunogen:	Vector containing the cDNA of mouse purinergic receptor P2X7.

Source/Host:	From rabbit.

Specificity:	Recognizes mouse purinergic receptor P2X7.

Application:	Flow Cytometry (1:100-1:400) Immunocytochemistry (1:100-1:400) Immunoprecipitation (1:100-1:400) Functional Application (blocking) (1:100-1:400)

Long Term Storage:	+4°C

Positive Control:	HEK cells transfected with an expression plasmid for mouse purinergic receptor P2X7 can be used as positive control.

Product Literature References

A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes: F. Scheuplein, et al.; J. Autoimmun. 34, 145 (2011), Abstract; Full Text

Differential regulation of P2X7 receptor activation by extracellular nicotinamide adenine dinucleotide and ecto-ADP-ribosyltransferases in murine macrophages and T cells: S. Hong, et al.; J. Immunol. 183, 578 (2009), Abstract; Full Text

NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells: F. Scheuplein, et al.; J. Immunol. 182, 2898 (2009), Abstract; Full Text

ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site: S. Adriouch, et al.; Faseb. J. 22, 861 (2008), Abstract; Full Text

Probing the expression and function of the P2X7 purinoceptor with antibodies raised by genetic immunization: S. Adriouch, et al.; Cell. Immunol. 236, 72 (2005), Abstract;

NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor: M. Seman, et al.; Immunity 19, 571 (2003), Abstract; Full Text