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Progranulin (human) polyclonal antibody

 
ALX-213-014-C100 100 µg 350.00 USD
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Product Specification

Alternative Name:Proepithelin, PC cell-derived growth factor, PEPI
 
Host:Guinea pig
 
Immunogen:Recombinant human progranulin.
 
UniProt ID:P28799
 
Species reactivity:Human
 
Crossreactivity:Cross-reacts with hGRN-C and hGRN-F. Weakly cross-reacts with mouse progranulin.
 
Applications:ELISA, WB
 
Recommended Dilutions/Conditions:ELISA (direct and indirect, 1:2,000-1:5,000)
Western Blot (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~90kDa by Western blot.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
 
Use/Stability:Stable for up to 6 months when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
 

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