LGP2 (human), pAb (AT137)



ALX-210-963-C050	50 µg	275.00 USD

Product Specification

Alternative Name:	Protein D11Lgp2 homolog, Probable ATP-dependent RNA helicase DHX58, Probable ATP-dependent RNA helicase LGP2

Concentration:	1mg/ml

Purity Detail:	Epitope-affinity purified.

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Immunogen:	Synthetic peptide corresponding to 15 aa near the C-terminus of human LGP2.

Source/Host:	From rabbit.

Specificity:	Recognizes human LGP2.

Application:	Immunoprecipitation (1:200) Western blot (1:1’000)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Miscellaneous/General:	MDA5 and RIG-I are two key intracellular receptors that recognize virus infection to produce type I IFN. LGP2 is homologous to MDA5 and RIG-I, but lacks the caspase recruitment domain (CARD) crucial for their antiviral activity. LGP2 may be a negative regulator of host innate immune defense against viruses by acting through dsRNA sequestration or inhibition of RIG-I dimerization.

General Literature References

Negative regulation of cytoplasmic RNA-mediated antiviral signaling: A. Komuro, et al.; Cytokine 43, 350 (2008), Abstract;

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity: M. Yoneyama, et al.; J. Immunol. 175, 2851 (2005), Abstract; Full Text