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Epstein-Barr Virus-induced Gene 3 (human) polyclonal antibody (AT136)

 
ALX-210-962-C100 100 µg 356.00 USD
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Product Specification

Alternative Name:IL-27B, Interleukin-27 subunit β, EBV-induced gene 3 protein, IL-27 subunit β, EBI3
 
Host:Rabbit
 
Immunogen:Recombinant human EBI3 (aa 21-229).
 
UniProt ID:Q14213
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation.
 

General Literature References

IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells: W. Niedbala, et al.; Eur. J. Immunol. 37, 3021 (2007), Abstract; Full Text
The inhibitory cytokine IL-35 contributes to regulatory T-cell function: L.W. Collison, et al.; Nature 450, 566 (2007), Abstract;
Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin: O. Devergne, et al.; PNAS 94, 12041 (1997), Abstract; Full Text

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Highly pure interleukin involved in T cell regulation.
Produced in HEK 293 cells. Human EBI3 (aa 21-229) linked to human IL-12A (aa 23-219) via the linker GGGSGGGSGGGSGGGS is fused at the C-terminus to the Fc portion of human IgG1 and a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF
 
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