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Viperin polyclonal antibody (AT131)

 
ALX-210-956-C100 100 µg 363.00 USD
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Product Specification

Alternative Name:Cig5, RSAD2, Cytomegalovirus-induced gene 5 protein, Radical S-adenosyl methionine domain-containing protein 2, Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa near the C-terminus of human viperin.
 
UniProt ID:Q8WXG1
 
Species reactivity:Human, Mouse
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Epitope-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Viperin has been identified as a human cytomegalovirus and IFN-γ inducible protein. Its expression is activated by both TLR3-dependent and RIG-I-dependent pathways. Viperin inhibits influenza A virus release of infected cells by altering plasma membrane fluidity and the formation of lipid rafts. It acts on the lipid rafts by decreasing the activity of the enzyme farnesyl diphosphate synthase (FPPS) which is essential for isoprenoid biosynthesis.
 
210-956
Figure: Detection of mouse Viperin in L929 cells by Western Blot using PAb to Viperin (AT131) (Prod. No. ALX-210-956) Method: Cell extracts from L929 cell either unstimulated (lane 1) or stimulated for 24h with poly(dA.dT) poly(dT.dA) at 3μg/ml (lane 2) were resolved by SDS-PAGE under reducing conditions, transferred to nitrocellulose and incubated with the PAb to Viperin (AT131) at a 1:1000 dilution for 1 hour. Proteins were visualized using a peroxidase-conjugated polyclonal antibody to rabbit IgG and a chemiluminescence detection system.
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210-956

General Literature References

TLR3 ligation activates an antiviral response in human fetal astrocytes: a role for viperin/cig5: M.A. Rivieccio, et al.; J. Immunol. 177, 4735 (2006), Abstract; Full Text
Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus: K.C. Chin & P. Cresswell; PNAS 99, 2460 (2002), Abstract; Full Text

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