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WIPI-1 (human) polyclonal antibody (AT129)

ALX-210-954-C050 50 µg 260.00 USD
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Product Specification

Alternative Name:WD repeat domain phosphoinositide-interacting protein 1, WD40 repeat protein interacting with phosphoinositides of 49kDa, Atg18 protein homolog, WIPI 49kDa
Immunogen:Synthetic peptide corresponding to aa of C-terminal human WIPI-1.
UniProt ID:Q5MNZ9
Species reactivity:Human
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Epitope-affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
WIPI-1 (human) polyclonal antibody (AT129) Western blot
Figure: Western blot analysis of human colorectal carcinoma cell lines HCT116 or RKO cells using PAb to WIPI-1 (human) (AT129)(Prod. No. ALX-210-954). Method: Total protein extracts from various human cell lines either untrasfected (lane 1), or transfected with a plasmid encoding human WIPI-I (lane 2) or with an empty plasmid (lane 3) were run on SDS-PAGE and WIPI-1 was detected by PAb to WIPI-1 (human) (AT129). Picture courtesy of Dr M.C. Maiuri, Guido Kroemer lab, Paris."
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WIPI-1 (human) polyclonal antibody (AT129) Western blot

General Literature References

Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007), Abstract;

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