Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

WIPI-1 (human) polyclonal antibody (AT129)

 
ALX-210-954-C050 50 µg 260.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:WD repeat domain phosphoinositide-interacting protein 1, WD40 repeat protein interacting with phosphoinositides of 49kDa, Atg18 protein homolog, WIPI 49kDa
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa of C-terminal human WIPI-1.
 
UniProt ID:Q5MNZ9
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Epitope-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:WIPI-1 (WD-repeat protein interacting with phosphoinosides) is highly expressed in a variety of tumors. It interacts with phosphatidylinositol-3-P and this interaction is required for recruitment to membranes. WIPI-1 contains the signature motif LXXLL for nuclear receptor association and it binds to estrogen and androgen receptors in vitro. The WIPI-1 homolog in S. cerevisiae (Atg18) plays a role in autophagy. WIPI-1 accumulates in multi-membrane structures under autophagic conditions and it co-localizes with LC3.
 
210-954
Figure: Western blot analysis of human colorectal carcinoma cell lines HCT116 or RKO cells using PAb to WIPI-1 (human) (AT129)(Prod. No. ALX-210-954). Method: Total protein extracts from various human cell lines either untrasfected (lane 1), or transfected with a plasmid encoding human WIPI-I (lane 2) or with an empty plasmid (lane 3) were run on SDS-PAGE and WIPI-1 was detected by PAb to WIPI-1 (human) (AT129). Picture courtesy of Dr M.C. Maiuri, Guido Kroemer lab, Paris.
Please mouse over
210-954

General Literature References

Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy: T. Proikas-Cezanne, et al.; FEBS Lett. 581, 3396 (2007), Abstract;

Related Products

WIPI-1 polyclonal antibody (AT130) 

WB | Print as PDF
 
ALX-210-955-C100 100 µg 354.00 USD
Do you need bulk/larger quantities?
 

Related Literature

Brochures
Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,