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PALB2 (human) polyclonal antibody (AT126)

 
ALX-210-951-C100 100 µg 320.00 USD
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Product Specification

Alternative Name:Partner and localizer of BRCA2, FANCN
 
Host:Rabbit
 
Immunogen:Recombinant human PALB2 (aa 1-200).
 
UniProt ID:Q86YC2
 
Species reactivity:Human
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (weak, 1:100)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:PALB2 (partner and localizer of BRCA2; FANCN) has been identified as a BRCA2 (breast cancer type 2) binding protein. PALB2 colocalizes with BRCA2 in nuclear foci, promotes its stability in key nuclear structurs (chromatin and nuclear matrix) and enables its recombinational repair and checkpoint functions. Mutations in the gene of PALB2 may contribute to breast cancer development (as well as prostate cancer). Mutations in PALB2 also cause Fanconi anemia.
 

General Literature References

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins: W. Wang; Nat. Rev. Genet. 8, 735 (2007), Abstract;
Fanconi anemia is associated with a defect in the BRCA2 partner PALB2: B. Xia, et al.; Nat. Genet. 39, 159 (2007), Abstract;
PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene: N. Rahman, et al.; Nat. Genet. 39, 165 (2007), Abstract;
The Fanconi anemia pathway and ubiquitin: C. Jacquemont & T. Taniguchi; BMC Biochem. 8 Suppl 1, S10 (2007), Abstract; Full Text
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2: B. Xia, et al.; Mol. Cell 22, 719 (2006), Abstract;

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