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ILEI polyclonal antibody (AT123)

 
ALX-210-948-C100 100 µg 323.00 USD
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Product Specification

Alternative Name:FAM3C, Interleukin-like EMT inducer
 
Host:Rabbit
 
Immunogen:Recombinant mouse ILEI (aa 25-227) (Prod. No. ALX-522-119).
 
UniProt ID:Q91VU0
 
Species reactivity:Human, Mouse
 
Applications:IP, WB
 
Recommended Dilutions/Conditions:Immunoprecipitation (1:200)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.
 

General Literature References

ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006), Abstract;
Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu; Genomics 80, 144 (2002), Abstract;

Related Products

ILEI (mouse), (recombinant) 

Produced in HEK 293 cells. Mouse ILEI (interleukin-like EMT inducer) (aa 25-227) is fused at the C-terminus to a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-522-119-C010 10 µg 377.00 USD
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