RIG-I (human), pAb (AT111)



ALX-210-932-C100	100 µg	280.00 USD

Product Specification

Alternative Name:	Probable ATP-dependent RNA helicase DDX58, Retinoic acid-inducible gene 1 protein, DEAD-box protein 58, RIG-1

Concentration:	1mg/ml

Purity Detail:	Protein A-affinity purified.

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Immunogen:	Recombinant human RIG-I (retinoic acid-inducible gene 1 protein) (aa 201-713).

Source/Host:	From rabbit.

Specificity:	Recognizes human RIG-I.

Application:	Immunoprecipitation (1:100) Western blot (1:1'000)

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored at -20°C.

Handling:	After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Miscellaneous/General:	RIG-I (retinoic acid-inducible gene I; Ddx58), a member of the DEAD-box RNA helicases, is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.

Product Literature References

Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils: N. Tamassia, et al.; J. Immunol. 181, 6563 (2008), Abstract;