SODD (human), pAb (AL169)

[BAG-4, BAG-family molecular chaperone regulator-4, Silencer of death domain]



ALX-210-919-C050	50 µg	226.00 USD

Product Specification

Concentration:	0.5mg/ml

Purity Detail:	Affinity purified.

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Immunogen:	Synthetic peptide corresponding to C-terminal aa 350-376 (N³⁵⁰AT SDHPNNQDQSSSLPEECVPSDEST³⁷⁶) of human SODD (Silencer of Death Domain; BAG-4; BAG-family Molecular Chaperone Regulator-4).

Source/Host:	From rabbit.

Specificity:	Recognizes human SODD. Detects bands of ~70kDa (full length protein) and ~60kDa (a C-terminal fragment) by Western blot.

Application:	Western Blot (1:1000) Note: Not recommended for immunoprecipitation.

Shipping:	SHIPPED ON BLUE ICE

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Handling:	Avoid freeze/thaw cycles.

Figure: Detection of endogenous SODD (human) in Jurkat (1) and HEK293T (2) cells using PAb to SODD (human) (AL169) (Prod. No. ALX-210-919).
Method: Total cell extracts (50µg) were run on a SDS-gel, and revealed with anti-SODD antibody (AL169, 1:1'000, in 5% milk powder) for 1 hour at RT followed by incubation with HRP-coupled anti-rabbit secondary antibody (1:4'000). Arrows indicate endogenous human SODD. Note that full length and a C-terminal fragment of SODD are detected.

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General Literature References

Apoptosis: Silencing the death receptors J. Tschopp, et al. Curr. Biol. 9 R381 (1999) Abstract Full Text

Overexpression of the 'silencer of death domain', SODD/BAG-4, modulates both TNFR1- and CD95-dependent cell death pathways H. Eichholtz-Wirth, et al. Cancer Lett. 194 81 (2003) Abstract