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United States 

SET (human) polyclonal antibody

 
ALX-210-917-C050 50 µg 220.00 USD
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Product Specification

Alternative Name:Phosphatase 2A inhibitor protein 2α, HLA-DR-associated protein 2, PHAPII, I2αPP2A, IGAAD, Inhibitor of granzyme-activated DNase, TAF-Iβ, Template-activating factor Iβ
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 3-16 (A3PAAKVSKKELNSN16) of human SETβ.
 
UniProt ID:Q01105
 
Species reactivity:Human
 
Applications:Flow Cytometry, ICC, IP, WB
 
Recommended Dilutions/Conditions:Flow Cytometry (1:100-1:200)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects endogenous protein by IP and WB.
 
Purity Detail:Protein A affinity-purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least one year after receipt if stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis: D. Martinvalet, et al.; Immunity 22, 355 (2005), Abstract;
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A: Z. Fan, et al.; Nat. Immunol. 4, 145 (2003), Abstract;
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003), Abstract;
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A: Z. Fan, et al.; Mol. Cell. Biol. 22, 2810 (2002), Abstract; Full Text
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks: P.J. Beresford, et al.; J. Biol. Chem. 276, 43285 (2001), Abstract; Full Text

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