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NM23-H1 polyclonal antibody (K73)

 
ALX-210-911-C100 100 µg 230.00 USD
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Product Specification

Alternative Name:GAAD, Granzyme A-activated DNase, NDPKA, NME1 NME2
 
Host:Rabbit
 
Immunogen:Recombinant human NM23-H1.
 
UniProt ID:P15531
 
Species reactivity:Human, Mouse
 
Specificity:Recognizes NM23-H1 and NM23-H2.
 
Crossreactivity:NM23-H2.
 
Applications:ICC, IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:100)
Immunohistochemistry (paraffin sections, 1:200)
Western Blot (1:100-1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein A-affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 

Product Literature References

Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility: L. Garzia, et al.; Oncogene 27, 1853 (2008), Abstract; Full Text
Overexpression of h-prune in breast cancer is correlated with advanced disease status: M. Zollo, et al.; Clin. Cancer Res. 11, 199 (2005), Abstract;
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis: A. D'Angelo, et al.; Cancer Cell 5, 137 (2004), Abstract;

General Literature References

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal: J. Lieberman; Nat. Rev. Immunol. 3, 361 (2003), Abstract;
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor: Z. Fan, et al.; Cell 112, 659 (2003), Abstract;
Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity: A. Forus, et al.; Oncogene 20, 6881 (2001), Abstract;
Evidence for interaction between human PRUNE and nm23-H1 NDPKinase: A. Reymond, et al.; Oncogene 18, 7244 (1999), Abstract;

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