NLRP1/NALP1 (human), pAb (AL176)



ALX-210-904-R100	100 µl	397.00 USD

Product Specification

Alternative Name:	NACHT-, LRR- and PYD-containing protein 1, DEFCAP, NAC, CARD7, Caspase recruitment domain-containing protein 7

Formulation:	Liquid. Neat serum containing 0.02% sodium azide.

Immunogen:	Synthetic peptide corresponding to aa 2-25 (A²GGAWGRLACYLEFLKKEELKEFQ²⁵) of N-terminal human NLRP1/NALP1 (NACHT-, LRR- and PYD-containing protein 1).

Source/Host:	From rabbit.

Specificity:	Recognizes human NLRP1/NALP1. Does not cross-react with mouse NLRP1/NALP1.

Application:	Western Blot

Short Term Storage:	+4°C

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored as recommended.

Handling:	Avoid freeze/thaw cycles.

Positive Control:	For Positive Control (Western blot) see Prod. No. ALX-840-603.

Figure: Western blot analysis of human and mouse cell lines with the anti-human NLRP1/NALP1 antibody (AL176) (Prod. No. ALX-210-904).Method: Total protein extracts (20µg) from various human (293-T, Jurkat, Raj, Ramos, BJAB, THP-1, U937, K562, Raw, HeLa) and mouse (EL-4, A20) cell lines were run on SDS-PAGE and NLRP1/NALP1 detected by Prod. No. ALX-210-904 at 1:500 dilution. Anti-rabbit IgG coupled horse radish peroxidase was used at 1:5000 dilution for ECL detection.

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Product Literature References

The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta: F. Martinon; Mol. Cell. 10, 417 (2002), Abstract;