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Troy polyclonal antibody

ALX-210-801-C100 100 µg 265.00 USD
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Product Specification

Alternative Name:TAJ, TNFRSF 19
Immunogen:Synthetic peptides corresponding to aa 29-44, 204-219 and 409-421 of human Troy (TAJ).
UniProt ID:Q9NS68
Species reactivity:Human, Mouse
Recommended Dilutions/Conditions:Western Blot (0.5-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~46kDa by Western blot.
Purity Detail:Protein G-affinity purified.
Formulation:Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:Troy is a membrane protein of 416 amino acids with characteristic cystene-rich motifs in the extracellular domain and a tumor necrosis factor receptor-associated factor (TRAF) 2 binding sequence in the cytoplasmic domain. Human Troy has 78% identity at the amino acid level with mouse Troy. The extracellular domain of Troy has significant homology with that of EDAR that specifies hair follicle fate. The cytoplasmic domain of Troy is different than other TNF receptor family members. Although its cytoplasmic domain does not contain death domain, Troy induced cell death is probably mediated through a caspase-independent pathway. Troy-induced JNK activation was not blocked by dominant-negative inhibitors of TRAF2, TRAF5, or ASK I, which have been previously implicated in JNK activation via TNF-R1 and CD40. However, coimmunoprecipitation assays revealed that Troy is capable of binding a number of different TRAF family members, and it is possible that Troy induced JNK activation is mediated by an as yet untested TRAF homolog, such as TRAF6. Troy mRNA is highly expressed in brain, prostate and embryo and moderately expressed in the heart, lung, liver.
Technical Info/Product Notes:Replacement for ADI-AAP-421
Figure: Western blot analysis of Troy using ALX-210-801 in T986, a human glioblastoma cell line lysate. A protein band of ~46kDa is detected.
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Product Literature References

TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration: Z. Shao, et al.; Neuron 45, 353 (2005), Abstract;

General Literature References

TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death: M.T. Eby, et al.; J. Biol. Chem. 275, 15336 (2000), Abstract; Full Text
TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles: T. Kojima, et al.; J. Biol. Chem. 275, 20742 (2000), Abstract; Full Text
Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia: A.W. Monreal, et al.; Nat. Genet. 22, 366 (1999), Abstract;

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