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TRAIL-R2 polyclonal antibody

 
ALX-210-743-C200 200 µg 356.00 USD
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Product Specification

Alternative Name:TRAIL receptor 2, DR5, Death receptor 5, KILLER, CD262, Trick2, Ly98, TNFRSF10B, TNF-related apoptosis-inducing ligand receptor 2, Tumor necrosis factor receptor superfamily member 10B
 
Host:Goat
 
Immunogen:Synthetic peptide corresponding to aa 68-94 (A68PQQKRSSPSEGL
CPPGHHISEDGRDC94) of the extracellular domain of human TRAIL-R2.
 
UniProt ID:O14763
 
Gene/Protein Identifier:8795 (Entrez GeneID)
 
Species reactivity:Human, Mouse
 
Applications:Flow Cytometry, ICC, IHC (PS), WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:300)
Immunohistochemistry (paraffin sections)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~52kDa by Western blot.
Cited applications include Immunoprecipitation.
 
Purity Detail:Epitope-affinity purified IgG.
 
Quality Control:Western Blot or Immunocytochemistry on cell lines HEK 293 or Jurkat.
 
Formulation:Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
 
Handling:For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
210-743
Figure: Specificity of PAb to TRAIL-R2. Lane 1: TRAIL-R3:Fc. Lane 2: TRAIL-R2. ALX-210-743 recognizes a band of approx. 46kDa of the expected size of the recombinant TRAIL-R2:Fc protein in lane 2 and shows no detectable cross-reactivity to TRAIL-R3:Fc in lane 1.
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210-743

Product Literature References

Death receptor 5 signaling promotes hepatocyte lipoapoptosis: S.C. Cazanave, et al.; J. Biol. Chem. 286, 39336 (2011), Application(s): Used for IP and ICC, Abstract;
Importance of TNF-related apoptosis-inducing ligand in pathogenesis of interstitial cystitis: O. Kutlu, et al.; Int. Urol. Nephrol. 42, 393 (2010), Abstract;
Lack of death receptor 4 (DR4) expression through gene promoter methylation in gastric carcinoma: K.H. Lee, et al.; Langenbecks Arch. Surg. 394, 661 (2009), Abstract;
High levels of endogenous tumor necrosis factor-related apoptosis-inducing ligand expression correlate with increased cell death in human pancreas: A.D. Sanlioglu, et al.; Pancreas 36, 385 (2008), Abstract; Full Text
Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al. ; Cell Death Differ. 11 Suppl 1, S86 (2004), Abstract;
Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5: T.G. Jin, et al.; J. Biol. Chem. 279, 55594 (2004), Abstract; Full Text
Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis: H. Higuchi, et al.; J. Biol. Chem. 278, 454 (2003), Abstract; Full Text
The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis: H. Higuchi, et al.; J. Biol. Chem. 276, 38610 (2001), Abstract; Full Text
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy: A.M. Chinnaiyan, et al.; PNAS 97, 1754 (2000), Abstract; Full Text

General Literature References

Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL: MacFarlane, et al.; J. Biol. Chem. 272, 25417 (1997), Abstract; Full Text
TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL: H. Walczak, et al.; EMBO J. 16, 5386 (1997), Abstract; Full Text

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