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DR6 (human) polyclonal antibody

ALX-210-569-C100 100 µg 306.00 USD
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Product Specification

Alternative Name:TNFRSF 21, Death receptor-6
Immunogen:Recombinant human DR6 (TNFRSF 21) (aa 370-655).
UniProt ID:O75509
Species reactivity:Human
Applications:ICC, WB
Recommended Dilutions/Conditions:Immunocytochemistry (3µg/ml)
Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Formulation:Liquid. In PBS.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
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Figure 1: Immunodetection of transfected human DR6 in HEK 293 cells using PAb to DR6 (human) (Prod. No. ALX-210-569). Asteriks represent N-glycosylated forms and arrow shows unglycosylated form of DR6.
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Figure 2: Immunocytochemical analysis of transfected human DR6 in HEK 293 cells using PAb to DR6 (human) (Prod. No. ALX-210-569). Confocal microscopy shows membrane localization of DR6; nuclei stained with DRAQ5 (Prod. No. BOS-889-001).
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Figure 3: Immunodetection of endogenous human DR6 in hematopoietic cells using PAb to DR6 (human) (Prod. No. ALX-210-569). Arrow represents unglycosylated form and asteriks shows alternatively translated form of DR6.
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Product Literature References

T-cell activation triggers death receptor-6 expression in a NF-kappaB and NF-AT dependent manner: M. Klima, et al.; Mol. Immunol. 48, 1439 (2011), Abstract;
Functional analysis of the posttranslational modifications of the death receptor 6: M. Klima, et al.; Biochim. Biophys. Acta 1793, 1579 (2009), Abstract;

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