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DNA polymerase β polyclonal antibody

ALX-210-553-R100 100 µl 280.00 USD
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Product Specification

Alternative Name:Pol β
Immunogen:Recombinant human Pol β (DNA polymerase β).
UniProt ID:P06746
Species reactivity:Human, Mouse
Recommended Dilutions/Conditions:Western Blot (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~45kDa by Western blot.
Formulation:Liquid. 100µl of antiserum in stabilization buffer containing 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:During base excision repair (BER) DNA polymerase β (Pol β) is recruited by APE1. Pol β has two distinct domains, the larger is the polymerase domain itself, whereas a small basic N-terminal domain contains an AP lyase activity that excises the abasic sugar-phosphate residue at the strand break. Pol β also interacts with XRCC1, DNA ligase III and poly(ADP-ribose) polymerase in the repair of DNA single strand breaks. Pol β plays a role in both BER pathways, "single-nucleotide" and "long patch". It is the most inaccurate of the six DNA polymerases found in mammalian cells. Overexpression of Pol β, as found in some human tumors, could confer an increase in spontaneous mutagenesis. It has been further suggested that Pol β does not excise 5’-oxidized AP sites induced by reactive oxygen species (ROS).

General Literature References

Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage: K. Ochs, et al.; Cancer Res. 59, 1544 (1999), Abstract; Full Text
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation: S. Grösch, et al.; Cancer Res. 58, 4410 (1998), Abstract; Full Text

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