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CD51 polyclonal antibody

 
ALX-210-537-R100 100 µl 301.00 USD
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Product Specification

Alternative Name:Vitronectin receptor α subunit, αV integrin
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to C-terminal portion of human CD51 (αV integrin) (aa 1021-1034) (cytoplasmic domain).
 
UniProt ID:P06756
 
Species reactivity:Species independent
 
Specificity:Recognizes the cytoplasmic domain of CD51.
 
Applications:ELISA, ICC, IHC (FS), IHC (PS), IP, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (1:1,000)
Immunohistochemistry (frozen sections, 1:500)
Immunohistochemistry (paraffin sections, 1:500)
Immunoprecipitation (5µl per 5x106 cells)
Western Blot (1:5,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Formulation:Liquid. Neat serum containing 0.05% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:CD51 (integrin αV subunit) associates with CD61 (integrin β3 subunit) binding to the RGD sequence in extracellular matrix proteins like vitronectin, fibrinogen, thrombospondin, von Willebrand factor and osteopontin. The αV/β3 heterodimer is expressed in endothelial cells, leukocytes, NK cells, macrophages, neutrophils, platelets and several malignant tumor cells and seems to play a role in embryo implantation, angiogenesis, wound healing and cancer. αV/β3  is also highly expressed in osteoclasts being important for bone resorption.
 

Product Literature References

Alpha v integrin subunit is predominantly located in nervous tissue and skeletal muscle during mouse development: E. Hirsch, et al.; Dev. Dyn. 201, 108 (1994), Abstract;

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