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Endothelin A receptor polyclonal antibody

 
ALX-210-507A-C250 250 µg 367.00 USD
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Product Specification

Alternative Name:ETA-receptor
 
Host:Sheep
 
Immunogen:Synthetic peptide corresponding to aa 410-422 (Q410EQNHNTERSSHK422) of C-terminal rat ETA-receptor (endothelin A receptor).
 
UniProt ID:P26684
 
Species reactivity:Human, Mouse, Rat
 
Specificity:Recognizes an epitope on the cytoplasmic side of the ETA-receptor.
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 4µg/ml)
Western Blot (10-20µg/ml using ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:As this antibody is generated against the cytosolic portion of endothelin A receptor, permeabilization is required for immunochemical analysis.
Detects bands of 34-52kDa by Western blot.
Does not block the binding of endothelins to the receptor.
 
Purity Detail:Epitope-affinity purified.
 
Formulation:Liquid. In TRIS-citrate-phosphate, pH 7-8, containing 0.1% sodium azide.
 
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.
 
210-507a
Figure: Immunohistochemical staining of invasive ductal carcinoma (G2) using PAb to Endothelin A Receptor (Prod. No. ALX-210-507A). Expression can be seen in the cytoplasma and in the cell membrane.
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210-507a

Product Literature References

Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer: P. Wulfing, et al.; Clin. Cancer Res. 10, 2393 (2004), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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