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Endothelin B receptor polyclonal antibody

 
ALX-210-506A-C250 250 µg 356.00 USD
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Product Specification

Alternative Name:ETB-receptor
 
Host:Sheep
 
Immunogen:Synthetic peptide corresponding to aa 424-437 (K424ANDHGYDN
FRSSNN437) of C-terminal rat ETB-receptor (endothelin B receptor).
 
UniProt ID:P21451
 
Species reactivity:Human, Mouse, Rat
Sheep
 
Specificity:Recognizes the cytoplasmic side of the ETB-receptor. Detects isoforms A and C in human.
 
Applications:IHC (FS), WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 2.5µg/ml)
Immunohistochemistry (frozen sections, 10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:This pAb was generated against the cytoplasmic portion of ETB-receptor, permeabilization is required for immunochemical analysis.
Detects bands of 34-52kDa by Western blot.
Does not block the binding of endothelins to the receptor.
 
Purity Detail:Epitope-affinity purified and sterile filtered.
 
Formulation:Liquid. In TRIS-citrate-phosphate buffer, pH 7-8, containing 0.1% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:+4°C
 
Long Term Storage:-20°C
 
Scientific Background:Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.
 
210-506a
Figure 1: Immunohistochemistry (frozen sections) using PAb to Endothelin B Receptor (Prod. No. ALX-210-506A) on rat superior mesenteric arteries. Arrow points at collagen bands, arrow head indicates ETB-receptor expression on smooth muscle cells.
210-506a 2
Figure 2: Immunohistochemical staining of invasive ductal carcinoma (G2) using PAb to Endothelin B Receptor (Prod. No. ALX-210-506A). Expression can be seen in the cytoplasma, in the cell membrane and in microvessels (arrow).
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210-506a 210-506a 2

Product Literature References

Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer: P. Wulfing, et al.; Clin. Cancer Res. 10, 2393 (2004), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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