Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Endothelin B receptor polyclonal antibody

ALX-210-506A-C250 250 µg Inquire for pricing
Do you need bulk/larger quantities?

Product Specification

Alternative Name:ETB-receptor
Immunogen:Synthetic peptide corresponding to aa 424-437 (K424ANDHGYDN
FRSSNN437) of C-terminal rat ETB-receptor (endothelin B receptor).
UniProt ID:P21451
Species reactivity:Human, Mouse, Rat
Specificity:Recognizes the cytoplasmic side of the ETB-receptor. Detects isoforms A and C in human.
Applications:IHC (FS), WB
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 2.5µg/ml)
Immunohistochemistry (frozen sections, 10µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:This pAb was generated against the cytoplasmic portion of ETB-receptor, permeabilization is required for immunochemical analysis.
Detects bands of 34-52kDa by Western blot.
Does not block the binding of endothelins to the receptor.
Purity Detail:Epitope-affinity purified and sterile filtered.
Formulation:Liquid. In TRIS-citrate-phosphate buffer, pH 7-8, containing 0.1% sodium azide.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:Endothelins are a family of peptides that are potent vasoconstrictors produced by mammalian vascular endothelial cells. The receptors for the endothelins are found on various tissues including, but not restricted to, lung and intestine.
Figure 1: Immunohistochemistry (frozen sections) using PAb to Endothelin B Receptor (Prod. No. ALX-210-506A) on rat superior mesenteric arteries. Arrow points at collagen bands, arrow head indicates ETB-receptor expression on smooth muscle cells.
210-506a 2
Figure 2: Immunohistochemical staining of invasive ductal carcinoma (G2) using PAb to Endothelin B Receptor (Prod. No. ALX-210-506A). Expression can be seen in the cytoplasma, in the cell membrane and in microvessels (arrow).
Please mouse over
210-506a 210-506a 2

Product Literature References

Endothelin-1-, endothelin-A-, and endothelin-B-receptor expression is correlated with vascular endothelial growth factor expression and angiogenesis in breast cancer: P. Wulfing, et al.; Clin. Cancer Res. 10, 2393 (2004), Abstract;

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,