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RANK (ectodomain) (human) polyclonal antibody

ALX-210-421-C050 50 µg 290.00 USD
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Product Specification

Alternative Name:TRANCE-R, ODFR, TNFRSF 11A, CD265, Receptor activator of NF-κB
Immunogen:Recombinant human RANK.
UniProt ID:Q9Y6Q6
Species reactivity:Human
Applications:Flow Cytometry, WB
Recommended Dilutions/Conditions:Western blot (1:2,000-1:5,000 using ECL; suggested blocking and dilution buffer is TBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~24kDa by Western blot.
Formulation:Liquid. Contains no preservatives.
Shipping:Shipped on Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C

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General Literature References

The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis: T. Wada, et al.; Nat. Med. 11, 394 (2005), Abstract;
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis: N. Nakagawa, et al.; Biochem. Biophys. Res. Commun. 253, 395 (1998), Abstract;
The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor: B.R. Wong, et al.; J. Biol. Chem. 273, 28355 (1998), Abstract;
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function: D.M. Anderson, et al.; Nature 390, 175 (1997), Abstract;

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